From the South
From Interstate 170 southbound, you'll take exit 7B.
From the North
Interstate 64/Hwy 40, take I-170 North to Exit 7c from the far left lane. You’ll be Westbound on I-70 for only a quarter-mile, then take Exit 238a.
From the West
Westbound on I-70 for only about a quarter-mile before you take exit 238A, which will take you past, in order: the East Terminal, the Main Terminal.
From the East
From St. Charles or Interstate 270 from St. Louis County or Illinois, you'll be approaching the airport Eastbound on I-70. Use exit 235C at Cypress Road.
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