From Pittsburgh
Go through Fort Pitt tunnels RT 279 South (approximately 11 miles). Follow 279 South to RT 22/30 to RT 60 North (same road, just changes names). Follow approximately 6-7 miles to Airport Exit #5.

From the North

Traveling Southbound on I-79
(for example from Erie, New York, etc.)
On I-79 South, exit 60B (Moon Run/Airport), RT 60 North towards airport (follow the airport signs). Travel approximately 12 miles to Airport Exit #6.

Via Beers School Road
Travelers' Alert: Due to the construction closure of the Flaugherty Run Road Exit, an alternate route to the airport is available. At the intersection of Beers School Road and Business 60, turn left onto Business 60 South. Travel approximately two miles and take the Airport Exit for 60 North to Pittsburgh International Airport.

From the South

Traveling Northbound on I-79
(for example, from West Virginia and Washington D.C.)
Exit #59B, RT 22/30 RT 60 (same road) towards airport. Follow RT 60 (bear left). Travel approximately 6-7 miles to Airport Exit #6.

From the West

Traveling Eastbound on I-80
(for example, from Ohio)
On I-80 East follow signs for PA Turnpike (I-76) Follow I-76 East until Exit #1A/11 (sign will say New Castle). Follow signs for Toll 60 South (Beaver/Pittsburgh). Airport is Exit #6

Steubenville OH/Weirton WV
Take 22/30 to Exit for RT 60 North and follow signs toward Airport. Travel approximately 12 miles to Airport Exit #6.

From the East

Traveling Westbound on I-376
(for example from Monroeville, PA Turnpike from Philadelpia, etc.)
Follow RT 376 West to Fort Pitt Bridge and Tunnel (follow overhead signs to the airport for correct lanes). Go through tunnels to RT 279 (approximately 11 miles). Follow 279 (Parkway West) to RT 22/30 to RT 60 North (same road just changes names). Follow RT 60 North (bear left), travel approximately 6-7 miles to Airport Exit #6.