From the North (Altamonte Springs, Sanford, etc.)
Take Interstate 4 to SR 417 (Greeneway) near Sanford
Take SR 417 (Greeneway) south to Orlando International Airport

Or,

Take Interstate 4 west to SR 408 (East-West Expressway) in downtown Orlando
Take SR 408 (East-West Expressway) east to SR 436 (Semoran Boulevard)
Take SR 436 (Semoran Boulevard) south to Orlando International Airport

Or,

Take Interstate 4 west to SR 528 (Bee Line/Beach Line Expressway) near International Drive/SeaWorld
Take SR 528 (Bee Line/Beach Line Expressway) east to Orlando International Airport (Exit 11B)

From the South/West (Tampa, Walt Disney World, Lake Buena Vista, etc.)
Take Interstate 4 east to SR 528 (Bee Line/Beach Line Expressway) near International Drive/SeaWorld
Take SR 528 (Bee Line/Beach Line Expressway) east to Orlando International Airport (Exit 11B)

Or,

Take Interstate 4 east to Exit 24E onto SR 417 (Greeneway) near Lake Buena Vista
Take SR 417 (Greeneway) north to Boggy Creek Road
Take Boggy Creek Road north to the South Entrance Road
Take the South Entrance Road north to Orlando International Airport

From the East (Port Canaveral, Cocoa Beach, Titusville, etc.)
Take Interstate 95 to SR 528 (Bee Line/Beach Line Expressway) near Cape Canaveral
Take SR 528 (Bee Line/Beach Line Expressway) west to Orlando International Airport (Exit 11B)

From the Florida Turnpike
Take the SR 528 (Bee Line/Beach Line Expressway) exit from the Turnpike
Take SR 528 (Bee Line/Beach Line Expressway) east to Orlando International Airport (Exit 11B)